Hepatoprotective effect of silymarin

[Panciu Corina-Maria]

The use of medicinal plants in treating illnesses has been reported since ancestral times. In the case of hepatic diseases, several species such as Silybum marianum, Phyllanthus niruri, and Panus giganteus (Berk.) have been shown to ameliorate hepatic lesions. Silymarin is a natural compound derived from the species Silybum marianum, which is commonly known as Milk thistle. This plant contains at least seven flavoligands and the flavonoid taxifolin. The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol, acetaminophen, and carbon tetrachloride. 

The liver is an important organ that has a key role in the maintenance of homeostasis. The liver is responsible for multiple metabolic functions and physiological processes such as bile production, energy generation, vitamin storage, and the metabolism of carbohydrates, proteins, and lipids. After intestinal absorption is complete the blood is rich in nutrients and xenobiotics. 

Silymarin is a natural compound that is present in species derived from Silybum marianum, which is commonly known as Milk thistle. The plant contains at least seven flavolignans and the flavonoid taxifolin. The most important flavolignans present include silybin, silydianin, and silychristine.

In previous studies, the inherent hepatoprotective and antioxidant activity of silymarin was shown to be caused by its control of free radicals (FR), which are produced by the hepatic metabolism of toxic substances such as Et-OH, acetaminophen (Paracetamol), or carbon tetrachloride. 

There is substantial evidence suggesting that silymarin treatment improves hepatic diseases. However, some of the data are contradictory. Therefore, additional molecular studies investigating the mechanisms of action for these compounds are needed. It is known that silymarin does not possess adverse effects at high doses. Thus, it is a natural compound that is widely utilized in traditional medicine and has been investigated in formal scientific studies. Diverse hepatic damage models and ethanol injury have been utilized to study silymarin because ethanol is responsible for many cases of liver damage worldwide. The current data demonstrate that the use of silymarin treatment in alcoholic cirrhosis patients may attenuate the damage. However, silymarin treatment does not affect mortality. Hepatoprotective effect of silymarin

[Pristavu Mircea-Cosmin]

Posteaza articole mai deosebite, toata lumea stie ca silimarina este buna pentru sanatatea ficatului.