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This work initiates the original and updated literature review of the current state of research on the Saniculoideae subfamily, emphasizing the selected genera Saniculeae, namely Sanicula, Hacquetia, Astrantia, and Eryngium. Various parts of these plants, especially aerial parts and roots, have an immense range of medicinal uses in traditional medicine for a number of ailments. Phytochemical studies conducted on the Saniculeae species indicate that these plants synthesize metabolites belonging to diverse groups of compounds. These include triterpenoid saponins, flavonoids, phenolic acids, coumarins, volatile organic compounds, polyacetylenes, ecdysteroids, phytosterols, lignans, betaines, carotenoids, and anthraquinones. https://link.springer.com/article/10.1007/s11101-024-10027-z

Lower urinary tract symptoms (LUTS) impact over 50% of the global adult population [82]. These symptoms emcompass storage, voiding, and post-micturition symptoms. Notably, overactive bladder (OAB) syndrome is classified as a specific subset within the domain of storage symptoms [2]. According to the International Continence Society (ICS), OAB describes the symptom complex of urinary urgency, often accompanied by increased frequency and nocturia, with or without urgency urinary incontinence, occurring in the absence of urinary tract infection or other obvious pathological coditions [54]. OAB is reconginized as a highly prevalent, troublesome and distressing condition. Its incidence tends to rise with age and it exerts a remarkable impact on quality of life (QOL). OAB affects both male and female equally, resulting in a large economic burden on individuals and society, in terms of the direct health care costs and lost productivity.https://link.springer.com/article/10.1186/s13020-024-00884-3

Keep calm and try omega-3. The fatty acids, available as dietary supplements via fish oil capsules and thought to help with mental and physical well-being, could also cut down on aggression, according to a recent study. These findings haven't come out of nowhere: omega-3 has previously been linked to preventing schizophrenia, while aggression and antisocial behavior are thought in part to stem from a lack of nutrition. What we eat can influence our brain's chemistry. https://www.sciencealert.com/one-dietary-supplement-found-to-reduce-aggression-by-up-to-28

Researchers created a water-soluble version of an important bacterial enzyme, which can now be used in drug screens to identify new antibiotics. A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a “hydrophobic” protein that loses its structure once removed from its normal location in the cell membrane.https://www.lifescience.net/news/5828/protein-study-could-help-researchers-develop-new-a/

In a study involving 11-year-olds, researchers have concluded that greater behavioral problems are linked to higher hair cortisol levels. The study also concluded that exposure to certain factors that can simultaneously cause chronic stress may determine the concentration of cortisol in the hair. https://www.sciencedaily.com/releases/2024/09/240903144923.htm

Given the right conditions, certain types of cells are able to self-assemble into new lifeforms after the organism they were once part of has died. Life and death are traditionally viewed as opposites. But the emergence of new multicellular life-forms from the cells of a dead organism introduces a "third state" that lies beyond the traditional boundaries of life and death .https://www.livescience.com/health/medicine-drugs/some-cells-can-enter-a-third-state-that-lies-beyond-the-traditional-boundaries-of-life-and-death-here-s-how

Researchers have shown that the balance of bacteria in the gut can influence symptoms of hypopituitarism in mice. They also showed that aspirin was able to improve hormone deficiency symptoms in mice with this condition.https://www.sciencedaily.com/releases/2024/09/240926144927.htm

Researchers have uncovered the mechanisms that protect the genome from the metabolic toxin formaldehyde in AMeD, a rare congenital disorder of premature aging and myeloid leukemia development. The thttps://www.sciencedaily.com/releases/2024/09/240912135838.htmeam used human cells and a new animal model to recapitulate AMeD symptoms and their findings open the door to new therapeutic interventions.

Each morning after breakfast, Scott Broadbent takes a plastic bottle from the refrigerator in his home in Alameda, Calif., pops the top, and drinks the contents, 2.5 ounces of milky liquid. “It has sort of a pineapple creamy flavor,” he says. “It’s really not bad.”https://www.sciencenews.org/article/aging-geroscience-health-span-drugs

Herbal supplements of ashwagandha (Withania somnifera) are typically made from extracts of its roots (some shown), which some say smell like a wet horse — hence its sanskrit name that means “horse smell.” Practitioners of Ayurveda — a traditional Indian medicine system — have used the ashwagandha plant for thousands of years. These days, another group is giving the plant a fresh surge of popularity. And while studies have found some benefits to supplements made from the plant, research gaps make it difficult to scientifically confirm many of ashwagandha’s purported properties.https://www.sciencenews.org/article/does-ashwagandha-improve-health

Canada has ordered 76 million doses of Covifenz, the main ingredient of which was manufactured in the leaves of a tobacco relative. Medicago uses Nicotiana benthamiana, a close relative of the tobacco plant, to manufacture virus-like particles that mimic SARS-CoV-2’s spike protein but don’t cause infection or disease. The particles are then harvested from the plants, purified, and combined with an immune-boosting adjuvant—made by British pharmaceutical company GlaxoSmithKline—to make the vaccine. The virus-like particles can be stored in a refrigerator at two to eight degrees celsius, unlike the mRNA vaccines that require extremely cold storage.https://www.the-scientist.com/canada-approves-world-s-first-plant-based-covid-19-vaccine-69745

In a recent study published in the journal Annals of Internal Medicine, researchers investigated whether short-term adverse effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger ribonucleic acid (mRNA) vaccinations are related to neutralizing antibody (nAB) responses. https://www.news-medical.net/news/20240611/Study-finds-short-term-side-effects-of-COVID-19-mRNA-vaccines-boost-long-term-antibody-response.aspx

A team of researchers from the Universitat Politècnica de València (UPV) and the CIBER de Bioingeniería, Biomaterials y Nanomedicine (CIBER-BBN) has developed an intelligent "nanokiller" based on a component of cinnamon essential oil (cinnamaldehyde) for use as an antimicrobial agent.https://phys.org/news/2024-05-team-intelligent-nanodevice-based-component.html

Regular use of fish oil supplements might increase, rather than lessen, the risk of first time heart disease and stroke among those in good cardiovascular health, but may slow progression of existing poor cardiovascular health and lower the risk of death, suggest the results of a large long term study, published in the open access journal BMJ Medicine.https://www.news-medical.net/news/20240521/Regular-use-of-fish-oil-supplements-linked-to-increased-heart-disease-risk-in-healthy-individuals.aspx

Currently available flu medications only target the virus after it has already established an infection, but what if a drug could prevent infection in the first place? Now, scientists have designed drug-like molecules to do just that, by thwarting the first stage of influenza infection.Currently available flu medications only target the virus after it has already established an infection, but what if a drug could prevent infection in the first place? Now, scientists have designed drug-like molecules to do just that, by thwarting the first stage of influenza infection.http://Drug-like inhibitor shows promise in preventing flu