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Currently available flu medications only target the virus after it has already established an infection, but what if a drug could prevent infection in the first place? Now, scientists have designed drug-like molecules to do just that, by thwarting the first stage of influenza infection.Currently available flu medications only target the virus after it has already established an infection, but what if a drug could prevent infection in the first place? Now, scientists have designed drug-like molecules to do just that, by thwarting the first stage of influenza infection.http://Drug-like inhibitor shows promise in preventing flu

The skin microbiota, with its millions of bacteria, fungi, and viruses, plays a key role in balancing the health of the skin and scalp. Its continuous exposure to potentially harmful stressors can lead to abnormalities such as local dysbiosis, altered barrier function, pathobiont overabundance, and infections often sustained by multidrug-resistant bacteria. These factors contribute to skin impairment, deregulation of immune response, and chronic inflammation, with local and systemic consequences. In this scenario, according to the needs of the bio-circular-green economy model, novel harmless strategies, both for regulating the diverse epidermal infectious and inflammatory processes and for preserving or restoring the host skin eubiosis and barrier selectivity, are requested. Vitis vinifera L. leaves and their derived extracts are rich in plant secondary metabolites, such as polyphenols, with antioxidant, anti-inflammatory, antimicrobial, and immunomodulatory properties that can be further exploited through microbe-driven fermentation processes. On this premise, this literature review aims to provide an informative summary of the most updated evidence on their interactions with skin commensals and pathogens and on their ability to manage inflammatory conditions and restore microbial biodiversity. The emerging research showcases the potential novel beneficial ingredients for addressing various skincare concerns and advancing the cosmeceutics field as well. https://www.mdpi.com/2079-6382/13/8/697

Researchers created a water-soluble version of an important bacterial enzyme, which can now be used in drug screens to identify new antibiotics. A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a “hydrophobic” protein that loses its structure once removed from its normal location in the cell membrane.https://www.lifescience.net/news/5828/protein-study-could-help-researchers-develop-new-a/

Each morning after breakfast, Scott Broadbent takes a plastic bottle from the refrigerator in his home in Alameda, Calif., pops the top, and drinks the contents, 2.5 ounces of milky liquid. “It has sort of a pineapple creamy flavor,” he says. “It’s really not bad.”https://www.sciencenews.org/article/aging-geroscience-health-span-drugs

Originar din Asia și cu o tradiție milenară, natto, produsul fermentării boabelor de soia, a fost asociat de-a lungul timpului cu o longevitate crescută, în special în cultura japoneză. https://pubmed.ncbi.nlm.nih.gov/3478223/ De la descoperirea sa inițială în 1987, nattokinaza a evoluat de la statutul de enzimă fibrinolitică la cel de moleculă cu multiple potențiale terapeutice. Pe lângă rolul său bine stabilit în prevenirea afecțiunilor trombotice, cercetările recente au dezvăluit efecte benefice ale nattokinazei asupra sistemului nervos, cardiovascular, precum și asupra sănătății respiratorii și a tractului respirator superior, acestea deschizand noi perspective în dezvoltarea de terapii inovatoare pentru o gamă largă de afecțiuni." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043915/ Studiile clinice au arătat că nattokinaza poate scădea tensiunea arterială prin reducerea rigidității arterelor și îmbunătățirea circulației sangvine, acționand prin scăderea nivelului de renină, o enzimă implicată în creșterea tensiunii arteriale. Datorită capacității sale de a reduce formarea cheagurilor de sânge și de a îmbunătăți circulația, prevenine infarctului miocardic. Având un profil de siguranță foarte bun și o absorbție eficientă in tractul digestiv, poate fi utilizată în siguranță pe termen lung pentru a reduce riscul bolilor cardiovasculare. Nattokinaza este capabilă să degradeze fibrilele amiloide la pH neutru și temperatură corporală normală, ceea ce sugerează un rol în tratarea bolilor legate de amiloid, cum ar fi boala Alzheimer (AD). În studiile recente, atât in vitro, cât și in vivo, s-a demonstrat că nattokinaza poate modula factorii specifici implicați în dezvoltarea bolii Alzheimer, reducând activitatea amiloid-β și a enzimei BACE-1, ceea ce indică o eficacitate neuroprotectoare; alt studiu a arătat că aceasta reduce semnificativ activitatea colinesterazei și nivelurile de IL-6, , ceea ce sugerează efecte proteolitice, antiinflamatoare și anti-apoptotice; în cazul accidentului vascular cerebral ischemic, nattokinaza a demonstrat un efect neuroprotector prin îmbunătățirea fluxului sanguin, prevenind agregarea plachetară și formarea cheagurilor. Legătura dintre sănătatea cardiovasculară și sănătatea cerebrală este evidentă, iar nattokinaza, prin efectele sale neuroprotectoare și asupra bolilor cerebrovasculare, ar putea aduce beneficii majore pentru pacienții cu risc cardiovascular și declin cognitive. Este deosebit de interesant să observăm că în fiecare an cercetările continuă să găsească beneficii clinice favorabile ca urmare a utilizării NK: https://www.mdpi.com/2305-6320/8/11/68 Prin descompunerea excesului de fibrina din plamani, nattokinaza ar putea ajuta la reducerea rigiditatii tesutului pulmonar, asociata cu fibroza pulmonara, reduce atât țesutul cicatricial pulmonar cât și cheagurile de sânge, imbunatatind astfel fuctia pulmonara si calitatea vietii. Această dublă acțiune este deosebit de benefică pentru pacienții cu BPOC, care se confruntă atât cu probleme de respirație, cât și cu un risc crescut de tromboembolism. Mai mult, prin degradarea fibrinei, nattokinaza contribuie la reducerea inflamației și a edemului la nivelul căilor respiratorii superioare, fiind utilă în tratamentul rinosinuzitei cronice.” Nattokinaza pare sa aiba potentiale benefice in sanatatea renala datorira capacitatii sale de a reduce coagularea sangelui, de a combate inflamatia si de a actiona ca un antioxidant, acestea fiind importante in gestionarea complicatiilor vasculare associate bolilor renale cronice si dializei.

Hello AnaM, Welcome to Forum Laboratoarele Medica. Please feel free to browse around and get to know the others. If you have any questions please don't hesitate to ask. The link to the official Pro-Natura website is : https://pro-natura.ro Forum Laboratoarele Medica staff.

Date recente sugerează disbioza microbiotei intestinale ca un factor care contribuie la bolile neurodegenerative, cum ar fi boala Parkinson (PD) și boala Alzheimer (AD), iar aceste patologii se pot manifesta prin axa microbiotă-intestin-creier, care cuprinde comunicarea bidirecțională prin neuroimun, neuroendocrine și căi neuronale directe, cum ar fi nervul vag. Datele din studiile clinice preclinice și umane dezvăluie un potențial interesant pentru ținte noi de tratament și modulare terapeutică cu prebiotice, plante medicinale, probiotice și simbiotice în sănătate, îmbătrânire și neurodegenerare și sunt revizuite aici. În timp ce în ultimul deceniu au fost dezvăluite mai multe perspective și caracterizare a axei microbiotă-intestin-creier, întrebările importante legate de patologia, patogeneza și tratamentul clinic al axei în contextul sănătății și al bolii neurodegenerative rămân și sunt discutate în acest articol. Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics, and Synbiotics

Avocado este bogat în fibre, antioxidanți și grăsimi sănătoase care pot susține sănătatea metabolică și sensibilitatea la insulină. Un nou studiu sugerează că consumul de avocado poate reduce semnificativ riscul de diabet, în special în rândul femeilor. Experții recomandă o dietă echilibrată și diversă, mai degrabă decât să accentueze prea mult alimentele specifice pentru prevenirea diabetului. Cu toate acestea, inclusiv avocado poate fi o alegere sănătoasă. O nouă cercetare publicată în Jurnalul Academiei de Nutriție și Dietetică sugerează o potențială asociere între consumul de avocado și riscul de diabet în rândul adulților mexicani. Diabetul este a doua cauză de deces în Mexic, afectând aproximativ 15,2% dintre adulți (12,8 milioane). Pentru a investiga relația dintre consumul de avocado și riscul de diabet, cercetătorii au studiat în mare parte obiceiurile alimentare auto-raportate și informațiile de diagnosticare a diabetului din răspunsurile la sondaj ale unei părți a populației mexicane. Majoritatea acestor respondenți au fost clasificați ca fiind supraponderali sau obezități. Rezultatele au arătat că femeile care au consumat avocado au avut mai puține șanse de a dezvolta diabet decât cele care nu le-au mâncat. Această legătură, însă, nu a fost observată la bărbați. https://www.medicalnewstoday.com/articles/regularly-eating-avocado-linked-to-lower-diabetes-risk-in-women

Altering gut bacteria in male mice revealed that microorganisms are needed for normal sperm development and offspring health. Scientists discuss the implications in terms of understanding microbes, male fertility and pregnancyhttps://www.nature.com/articles/d41586-024-01191-5

Blasting a patch of patients’ stomach lining with thermal energy curbed hunger and cut pounds, researchers reported in a small pilot study to be presented at the annual Digestive Disease Week meeting on May 19 in Washington, D.C. The study’s authors pinned participants’ weight loss on reduction of a hunger hormone called ghrelin. The hormone acts like a dinner bell for the brain, sending the message that it’s time to eat. Less ghrelin means fewer hungry feelings. There isn’t a drug available to lower the hormone’s level in the blood, but doctors can directly target the tissue that makes ghrelin. Cells lining the upper portion of the stomach pump out most of the hormone. Burning these cells away should lead to weight loss, reasoned study coauthor Christopher McGowan, a gastroenterologist at True You Weight Loss, a clinic in Cary, N.C. https://www.sciencenews.org/article/burn-stomach-lining-ghrelin-weight-loss Doctors threaded an endoscope (black tube) down a patient’s throat and into their stomach (left). Then, they burned away a patch of tissue lining the upper part of the organ (gray section, right). That destroyed cells that produce a key hunger hormone. Ideea e a inca nu exista tratament sau remediu pentru/impotriva hormonului *grelina* care provoaca foamea la oameni. Am putea sa facem o cercetare in culturile antice, si cu cunostintele pe care le mai are domnu doctor am putea crea un remediu natural impotriva acestui hormon/foamei, astfel nu am mai fii nevoiti sa distrugem parti din corpul nostru.

99% ingrediente de origine naturala. Cu ulei de ricin, avocado, masline si muscata, unt de shea, extract de grau si morcov. Fara parabeni, parfum sau coloranti, Perfecta pentru femeile insarcinate sau proaspetele mamici. Preturi: 60 lei pentru 500ml/flacon

Aim: The aim was to evaluate the analgesic, anti-inflammatory, and anti-hyperlipidemic activities of Commiphora molmol extract (CME) and its effects on body weight and blood lipids. Materials and Methods: The analgesic effect was assessed using thermal (hot plate test) and chemical (writhing test) stimuli to induce central and peripheral pain in mice. The anti-inflammatory activity was determined using formalin-induced paw edema in rats. For anti-hyperlipidemic effect, 25 rats were randomly divided into five groups (n = 5). Group 1 was fed on basal diet (normal control), while the other four groups were fed on high-fat diet for 6 weeks to induce obesity and hyperlipidemia. Thereafter, Group 2 was kept obese hyperlipidemic, and Groups 3, 4 and 5 were orally given CME in doses of 125, 250, and 500 mg/kg for 6 weeks, respectively. Body weight gains of rats were calculated, and blood samples were collected for analysis of blood lipids. Results: CME produced a dose-dependent analgesic effect using both hot plate and writhing tests in mice. The hot plate method appeared to be more sensitive than writhing test. CME exhibited an anti-inflammatory activity as it decreased volume of paw edema induced by formalin in rats. The extract decreased body weight gain; normalized the high levels of blood lipids and decreased atherogenic index low-density lipoprotein/ high-density lipoprotein in obese hyperlipidemic rats. Conclusion: The results denote that C. molmol extract (myrrh) has significant analgesic, anti-inflammatory and anti-hyperlipidemic effects and reduces body weight gain and improves blood lipids profile. These results affirm the traditional use of C. molmol for the treatment of pain, inflammations, and hyperlipidemia. Analgesic, anti-inflammatory and anti-hyperlipidemic activities of Commiphora molmol extract (Myrrh)

Ononis spinosa L. is a plant traditionally used as folk remedy. There are numerous studies regarding chemical constituents and health beneficial properties of Ononidis Radix. The following study was designed to investigate chemical composition and antifungal potential of the methanolic extract obtained from the O. spinosa L. herb. Chemical analyses regarding phenolic compounds of O. spinosa were performed by liquid chromatography with mass spectrometry (LC-DAD-ESI/MSn). Antifungal activity, antibiofilm properties and antifungal mode of action of the extract were evaluated, as well as cytotoxicity. Chemical analyses revealed the presence of flavonoids, isoflavonoids and phenolic acids in O. spinosa, with kaempherol-O-hexoside-pentoside being the most abundant compound (5.1 mg/g extract). Methanolic extract was active against all of the tested microfungi with Penicillium aurantiogriseum being the most sensitive to the extract inhibitory effect at 0.02 mg/mL; and effectively inhibited biofilms formed by Candida strains. Minimum fungicidal concentrations of extract rose in the presence of ergosterol and leakage of cellular components was detected. The extract showed no cytotoxicity to human gingival fibroblast (HGF-1) cells. This study significantly contributes to overall knowledge about medicinal potential of O. spinosa herbal extract and enlightens previously unrevealed properties. O. spinosa aerial parts seem to be an interesting candidate for the development of antifungal preparations, non-toxic to human cells. Methanolic Extract of the Herb Ononis spinosa L. Is an Antifungal Agent with no Cytotoxicity to Primary Human Cells

Essential oils from plants have been proven safe as natural antioxidants, and few are already marketed as digestive enhancers as well as in prevention of several degenerative diseases. This study evaluated the antioxidant capacity of seed and shell essential oils of Abrus precatorius (L), a herb used for ethno-medicinal practices in Nigeria. The essential oils were obtained by hydro-distillation. The ability of the oils to act as hydrogen/electrons donor or scavenger of radicals were determined by in-vitro antioxidant assays using 2,2-diphenyl-2-picryl-hydrazyl free radical (DPPH.) scavenging; 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging; lipid peroxide and nitric oxide radicals scavenging assays. The IC50 of the seed and shell oils (2.10 mg/mL and 1.20 mg/mL respectively) showed that antioxidant activity is higher than that for the standard drugs (3.20 mg/mL and 3.40 mg/mL) for the nitric oxide scavenging assay. The lipid peroxidation radical activity of the oils were similar to vitamin C, weak DPPH and ABTS radical scavenging activities were discovered in comparison to vitamin C and rutin. Generally, in the four antioxidant assays, a significant correlation existed between concentrations of the oils and percentage inhibition of free radicals and lipid peroxidation. The composition of A. precatorius essential oils reported earlier may account for their antioxidant capacity. This study shows that besides the traditional uses of the plant extract, the essential oils extracted from A. precatorius seeds and shells have good antioxidant potential, and could probably replace synthetic antioxidants in further studies. Antioxidant and Free Radical Scavenging Capacity of Seed and Shell Essential Oils Extracted from Abrus precatorius (L)

Helleborus purpurascens Waldst. & Kit. (Helleborus purpurascens L.) from the Ranunculaceae family has been used as a medicinal plant in Romanian and European ethnomedicine for centuries . One of the first mentions of the therapeutic effect of this plant occurs in Diseases of Women by Hippocrates. Also, the use of the plant in Dacian medicine is reported in De Materia Medica. In traditional European medicine, hellebore is used for its antimicrobial, anti-inflammatory, antitumor, cardiotonic, analgesic, antiseizure, laxative and other effects. Modern Romanian studies from the end of the last century have demonstrated the therapeutic potential of the plant in the treatment of severe forms of rheumatism. Recent research has confirmed their unique antitumor and immunomodulating activity. The undertaken study describes the low-molecular-mass metabolite profiling of Helleborus purpurascens growing wild in Romania. The biological activities of each category of phytoconstituents were discussed. Furthermore, a new phyto-carrier system (hellebore-AgNPs system) with unique physical–chemical characteristics and high antioxidant activity was prepared. The encapsulation potential of the plant samples (i.e., hellebore) and new phyto-carrier system (hellebore-AgNPs system) in chitosan nanoparticles (CNs) was evaluated. The development of two new phyto-nanocarriers, HC and HAgC, was confirmed through FTIR, EDX, XRD, DLS and SEM studies. The thermal stability was investigated. Several different antioxidant assays (DPPH, Folin–Ciocalteu, phosphomolybdate (total antioxidant capacity) and iron(III)-phenanthroline antioxidant) were carried out to ensure that HC and HAgC exhibited potent antioxidant activity. Collectively, this study shows the potential advantages of these phyto-nanocarriers encapsulated as selective therapeutic delivery systems. Nonetheless, further studies are necessary to investigate the in vitro release, biological properties and bioavailability of these new phyto-nanocarriers. Wild-Grown Romanian Helleborus purpurascens Approach to Novel Chitosan Phyto-Nanocarriers—Metabolite Profile and Antioxidant Properties

This work initiates the original and updated literature review of the current state of research on the Saniculoideae subfamily, emphasizing the selected genera Saniculeae, namely Sanicula, Hacquetia, Astrantia, and Eryngium. Various parts of these plants, especially aerial parts and roots, have an immense range of medicinal uses in traditional medicine for a number of ailments. Phytochemical studies conducted on the Saniculeae species indicate that these plants synthesize metabolites belonging to diverse groups of compounds. These include triterpenoid saponins, flavonoids, phenolic acids, coumarins, volatile organic compounds, polyacetylenes, ecdysteroids, phytosterols, lignans, betaines, carotenoids, and anthraquinones. https://link.springer.com/article/10.1007/s11101-024-10027-z

Origanum vulgare L. (oregano, wild marjoram), an herbaceous Mediterranean species of the Lamiaceae family, comprises several subspecies such as hirtum Ietsw., vulgare L., viridulum (Martrin-Donos) Nyman, glandulosum (Desfontaines) Ietswaart, gracile (Koch) Ietsw., virens (Hoffmanns. & Link) Ietsw., and viride L.. In Romania, the most widespread O. vulgare species is O. vulgare ssp. vulgare . In terms of chemical composition, research on O. vulgare species from various countries have previously been reported: Italy , Greek , Serbia, Egypt , Pakistan , China , India , Iraq , Macedonia . Representatives of the following important classes of active principles were revealed: essential oil (with carvacrol and/or thymol, linalool, and p-cymene), polyphenols (flavonoids and phenolic acids), triperpenoids, and sterols . European oregano has been traditionally used since ancient times for its carminative, stomachic, emmenagogue, and expectorant effects to treat cramps, flatulence, coughs, or menstrual problems . Origanum vulgare’s longstanding use in traditional medicine attracts even greater interest in designing new pharmaceutical formulations in various areas. New investigations have shown many therapeutic properties: antimicrobial , antiviral , antioxidant , anti-inflammatory , antispasmodic, antiurolithic, antiproliferative , neuroprotective, etc. Because of its high antioxidant activity, O. vulgare is an important natural source for the preservation of different food or cosmetics . This study provides data on the chemical and biological characterization of the spontaneous Romanian Origanum vulgare ssp. vulgare. In the ethanolic extract of oregano, four phenolic acids (gentisic, chlorogenic, p-coumaric and rosmarinic acids) and six flavonoids (hyperoside, isoquercitrin, rutin, quercitrin, quercetin and luteolin) were identified by HPLC-MS. The biological effects, particularly the antioxidant, antimicrobial and hepatoprotective, were significant. The antioxidant activity, evaluated using CUPRAC, FRAP, inhibition of lipid peroxidation catalyzed by cytochrome c, and SO scavenging assays, indicated that O. vulgare extract had a high antioxidant potential, in line with the total polyphenolic content.Origanum vulgare ssp. vulgare: Chemical Composition and Biological Studies

Uleiurile esențiale sunt un amestec de uleiuri volatile aromatice naturale extrase din plante. Utilizarea uleiurilor esențiale este străveche și a predominat în diferite culturi din întreaga lume, cum ar fi cele ale egiptenilor, grecilor, perșilor și chinezi. Astăzi, uleiurile esențiale sunt folosite în medicamentele tradiționale și complementare, aromoterapie, terapii de masaj, cosmetice, parfumuri și industriile alimentare. Efectul de screening al uleiurilor esențiale a fost studiat în întreaga lume. Ele demonstrează o serie de activități biologice, cum ar fi proprietăți antiparazitare, antifungice, antibacteriene, antivirale, antioxidante, antiinflamatorii, anticancerigene, antiimbatranire și neuroprotectoare. În această analiză a domeniului de aplicare, oferim o evaluare cuprinzătoare actualizată de 10 ani a uleiurilor volatile și a efectelor acestora asupra sistemului nervos. MEDLINE, Scopus și Google Scholar au fost căutate sistematic și strategic pentru studii originale care investighează aceste efecte din 2012 până în 2022. Aproximativ șaptezeci de studii au fost selectate ca studii incluse. Printre aceste studii, au fost raportate mai multe rezultate, inclusiv efecte antistres, antianxietate, analgezice, cognitive și autonome. Unele uleiuri esențiale au prezentat beneficii pentru dezvoltare, cu potențialul de a induce creșterea neuriților. Nivelul receptorului neurotransmițătorului poate fi modificat și prin aplicarea uleiurilor esențiale. Au fost raportate măsuri de rezultat fiziologic și fiziopatologic. Pentru rezultatele fiziologice, au fost investigate excitarea, performanța cognitivă, comportamentul alimentar circadian, modularea emoțională, acceptarea consumatorului, preferințele și disponibilitatea de a cumpăra. Pentru afecțiunile fiziopatologice au fost măsurate durerea, depresia, anxietatea, stresul, tulburările de somn, oboseala mentală, comportamentul agitat și calitatea vieții. În concluzie, uleiurile esențiale au arătat efecte promițătoare asupra sistemului nervos, care pot fi aplicate în continuare utilizării lor în alimente funcționale, băuturi și terapie alternativă. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180368/

The demographic situation of the last few decades is characterized by the increased numbers of elderly and senile people, i.e., by the aging of the population. In humans, ageing is closely associated with the enhanced production of reactive oxygen species (ROS), development of systemic inflammation and related vascular atherosclerotic alterations and metabolic disorders, like obesity, diabetes mellitus and neurodegenerative diseases. As these age-related alterations are directly associated with up-regulation of ROS production and development of chronic oxidative stress, their onset can be essentially delayed by continuous daily consumption of dietary antioxidants—natural products of plant origin. Such antioxidants (in the form of plant extracts, biologically active complexes or individual compounds) can be supplemented to functional foods, i.e., dietary supplementations for daily diet aiming prolongation of active life and delay of the senescence onset. Thereby, use of widely spread medicinal plants might essentially improve cost efficiency of this strategy and availability of antioxidant-rich functional foods. Therefore, here we addressed, to the best of our knowledge for the first time, the antioxidant activity of the extracts prepared from the aerial parts of Filipendula ulmaria and Alnus glutinosa growing in the Kaliningrad region of Russia, and assessed the contents of the biologically active substances underlying these properties. It was found that the extract prepared with the leaves of Filipendula ulmaria and female catkins of Alnus glutinosa demonstrated high antioxidant activity, although the former plant was featured with a higher antioxidant potential. The highest antioxidant activity detected in the methanol extracts of Alnus glutinosa reached 1094.02 ± 14.53 µmol TE/g, radical scavenging of activity was 584.45 ± 35.3 µmol TE/g, reducing capacity at interaction with iron complex—471.63 ± 7.06 µmol TE/g. For the methanol extracts of Filipendula ulmaria the antioxidant activity reached 759.78 ± 19.08 µmol TE/g, antioxidant activity for free radical removal was 451.08 ± 24.45 µmol TE/g and antioxidant activity for restorative ability with iron complex was 332.28 ± 10.93 µmol TE/g. These values are consistent with the total yields of the extracts and their content of ellagic acid. The ethyl acetate extracts of the both plants showed just minimal antioxidant activity. Thus, the considered extracts have an essential potential. This creates good prospects for the further use of herbal extracts of Filipendula ulmaria and Study of the Antioxidant Properties of Filipendula ulmaria and Alnus glutinosa as a source of natural antioxidants.

Since the introduction of bioabsorbable magnesium alloys into cardiovascular stent technology, many researches have been conducted to improve these metallic scaffolds. Various coatings and different coating techniques, super plastic deformation techniques and synthesizing different Mg-based alloy are examples of such efforts. In this study, a magnesium based alloy (WE43) was coated with dexamethasone loaded polymeric nanoparticles via electrospraying method. Drug release behavior, drug inhibitory effects, surface properties and cell responses to the surface were evaluated. Drug release profile was investigated and compared to drug-loaded nanoparticle on stainless steel as a control. The inhibitory effects of the drug-loaded nanoparticle coatings on smooth muscle cells was evaluated via MTT assay. Endothelial cells response to the surface was investigated by SEM. The results showed that contact angle and roughness of the surface were 131° and 600–800 nm, respectively. https://www.sciencedirect.com/science/article/abs/pii/S1350453322001266

Alchemilla vulgaris L. (lady’s mantle) was used for centuries in Europe and Balkan countries for treatments of numerous conditions and diseases of the reproductive system, yet some of the biological activities of lady’s mantle have been poorly studied and neglected. The present study aimed to estimate the potential of A. vulgaris ethanolic extract from Southeast Serbia to prevent and suppress tumor development in vitro, validated by antioxidant, genoprotective, and cytotoxic properties. A total of 45 compounds were detected by UHPLC–HRMS analysis in A. vulgaris ethanolic extract. Measurement of antioxidant activity revealed the significant potential of the tested extract to scavenge free radicals. In addition, the analysis of micronuclei showed an in vitro protective effect on chromosome aberrations in peripheral human lymphocytes. A. vulgaris extract strongly suppressed the growth of human cell lines derived from different types of tumors (MCF-7, A375, A549, and HCT116). The observed antitumor effect is realized through the blockade of cell division, caspase-dependent apoptosis, and autophagic cell death. In addition, this medicinal plant exhibits antibacterial, antifungal, and antiviral properties . In the context of bacterial resistance to antibiotics, plant drugs and extracts are considered potent antibacterial agents without the risk of a further increase in resistance to standard antimicrobial agents. A recent study targeting the effects of the lady’s mantle infusion after hypoxic exposure indicated the neuroprotective properties of the plant drug . Neagu et al. , demonstrated the acetylcholinesterase and tyrosinase inhibitory effect of Alchemilla vulgaris extract, and therefore it was assumed that the species could be used in the prevention and treatment of neurodegenerative diseases . The results of this study strongly support the historically collected data about the healing potential of Alchemilla vulgaris L. from Southeast Europe, which was traditionally used as a medicinal plant for centuries. This study confirmed that the ethanolic extract of Alchemilla vulgaris L. represents a valuable source of bioactive compounds with multiple beneficial biological properties, including strong antitumor activity and remarkable genoprotective features resulting, at least partly, from the strong antioxidant potential of this plant.Beyond Traditional Use of Alchemilla vulgaris: Genoprotective and Antitumor Activity In Vitro

De ce este fierul atât de important pentru sănătate? Fierul este un nutrient esențial care joacă o gamă largă de roluri în corpul uman. Poate cel mai faimos, este o componentă importantă a hemoglobinei, care transportă oxigenul în sânge. De asemenea, este important pentru o serie de procese metabolice, inclusiv sinteza ADN și producerea de energie. O afecțiune comună cauzată de rezervele scăzute de fier este anemia cu deficit de fier, dar fierul inadecvat este, de asemenea, asociat cu o serie de alte afecțiuni de sănătate. De exemplu, potrivit autorilor noului studiu, deficitul de fier este, de asemenea, legat de: sindromul picioarelor nelinistite, scăderea capacității fizice, funcția cerebrală afectată, insuficienţă cardiacă, risc crescut de deces. „Aportul excesiv de fier poate provoca efecte secundare gastrointestinale sau chiar supraîncărcare cu fier, care se numește hemocromatoză” Cea mai cunoscută sursă de fier este carnea roșie. Fierul din surse animale se numește fier hem, în timp ce fierul din plante este denumit fier non-hem. Dintre cele două, fierul hem este mult mai ușor de absorbit de către organism. În ceea ce privește sursele pe bază de plante, „alimentele cu fier non-hem includ cereale integrale, verdeață închisă cu frunze, tofu, nuci și semințe”. https://www.healthline.com/health-news/iron-deficiency-healthy-tips-to-get-more-iron#Takeaway

Antiepileptic drugs (ADEs) are now used to treat a wide range of neurological problems, although their usage is still restricted due to their side effects, particularly hepatotoxicity. Thus, this study consists of the therapeutic effects of non-conditioned Mesenchymal Stem Cells (MSCs) and the MSCs preconditioned with cherry extract (MSCs CM) on mitigation of liver damage induced by the dual administration of antiepileptic drugs such as Levetiracetam (L) and Oxcarbazepine (O). https://www.sciencedirect.com/science/article/pii/S1018364723002835

Lower urinary tract symptoms (LUTS) impact over 50% of the global adult population [82]. These symptoms emcompass storage, voiding, and post-micturition symptoms. Notably, overactive bladder (OAB) syndrome is classified as a specific subset within the domain of storage symptoms [2]. According to the International Continence Society (ICS), OAB describes the symptom complex of urinary urgency, often accompanied by increased frequency and nocturia, with or without urgency urinary incontinence, occurring in the absence of urinary tract infection or other obvious pathological coditions [54]. OAB is reconginized as a highly prevalent, troublesome and distressing condition. Its incidence tends to rise with age and it exerts a remarkable impact on quality of life (QOL). OAB affects both male and female equally, resulting in a large economic burden on individuals and society, in terms of the direct health care costs and lost productivity.https://link.springer.com/article/10.1186/s13020-024-00884-3

This study aims to evaluate the properties of essential oils (EOs) from cinnamon (Cinnamomum cassia) and clove (Eugenia caryophyllus). Mixtures of cinnamon and clove EOs at ratios of 75:25, 50:50, and 25:75 were encapsulated and applied in fresh sausage. The research includes a kinetic examination of active component release and preservation parameter monitoring. Clove EO showed superior antioxidant activity (0.039 mg/mL), while cinamon oil exhibited promising bacterial inhibition (minimum inhibitory concentration lower 1.5). Combinations of cinnamon and clove EOs demonstrated synergistic antioxidant and antimicrobial effects. Encapsulation efficiency for the 25:75 cinnamon and clove oil mixture reached 89.4%, with 80.9% EO retention. The microencapsulated mixture displayed commendable antimicrobial and antioxidant activities, slowing compound release (>50% after 15 days). https://www.sciencedirect.com/science/article/abs/pii/S2212429224010794

Aristolochia is the largest genus of the Aristolochiaceae family which is widespread throughout the North Africa and Europe Asia. In the traditional systems of Indian medicine, Aristolochia clematitis is used as stomachic, an astringent in dentistry, used against gastric disorders, headache, snake bite poisoning, toothache and fever. In addition, the decoctate of the plant is used for the treatment of the ulcer (Iserin et al., 2001). Furthermore, Theophraste (372-286 before J.-C.) reported that A. clematitis is popularly used for treating uterus dysfunction, snake bite, stomach complaints and the wound. Moreover, this plant is used for a long time as disinfectant and helps in childbirth. In South Algeria, and in addition to the medicinal uses of A. clematitis described above, the population uses this plant as antitumor and anticancer. Chemically, the plants of the genus Aristolochia L. are known to contain phenanthrene derivatives of which predominantly aristolochic acids cause fagocytosis of leukocytes and also reveal antitumour (Wall et al., 1987) and genotoxic (Mengs and Klein, 1988) activities. Moreover, phenylpropane derivatives (Lopes et al., 1987) and alkaloids belonging to bisbenzylisoquinoline and aporphine (Chakravarty et al., 1988, Rücker and Mayer, 1985) groups were reported in this family. The plant A. clematitis L. has been known to contain several constituents such as aristolochic acids, aristolactam N-ß-D-glucoside, magnoflorine iodide, aristolone, β-sitosterol, sitosterol β-D-glucoside, ferulic (4-hydroxy-3-methoxycinnamic), 4-coumaric (4-hydroxycinnamic) acids, and methyl ester (Kostalova et al., 1991). In vitro antioxidant activity was carried out with tannins and methanolic extracts by the DPPH free radical scavenging method. The IC50 value was determined for each extract. From the results of the DPPH method, it was found that tannin extract displayed strong antioxidant activity as ascorbic acid and methanolic extract. In this study, DPPH radical scavenging activity of tannins and methanolic extracts were applied to determine their kinetic behaviour. The tannin extract showed very fast kinetic action compared to the methanolic extract, which is probably a result of the different kinetic behaviour of antioxidants present in A. clematitis roots. The main conclusion is that extracts under study are effective as scavengers of free radicals and can be used as a source of new low cost antioxidants. In vitro antioxidant activity was carried out with tannins and methanolic extracts by the DPPHradical dot free radical scavenging method. The IC50 value was determined for each extract. From the results of the DPPH method, it was found that tannin extract displayed strong antioxidant activity as ascorbic acid and methanolic extract. In this study, DPPHradical dot radical scavenging activity of tannins and methanolic extracts were applied to determine their kinetic behaviour. The tannin extract showed very fast kinetic action compared to the methanolic extract, which is probably a result of the different kinetic behaviour of antioxidants present in A. clematitis roots. The main conclusion is that extracts under study are effective as scavengers of free radicals and can be used as a source of new low cost antioxidants.

Potentilla anserina L. (silverweed) is a low-growing herbaceous plant of the Rosaceae family. It is found in the temperate zone around the globe and most commonly on sandy or rocky clay soils in Europe, Siberia, the Far East, and Central Asia. Remedies containing P. anserina total herb are widely used in various folk and medical systems, particularly in traditional Tibetan medicine and folk medicine. In Tibetan medicine, P. anserina herb is used for infectious diarrhea with fever, while its roots and rhizomes are applied as an antiseptic remedy. In Yakutian medicine, the tincture from P. anserina flowers in vodka is used as an antidiarrheal remedy; the water decoction from flowers and leaves is applied for kidney and liver diseases, respectively. The gruel from the fresh leaves is used as a wound-healing agent . In Chinese medicine, the whole plant is applied for the treatment of hematemesis . Traditionally, Mongolian arats (cattle-breeders) applied P. anserina as an astringent and bactericidal remedy for treatment of enterocolitis and dyspepsia . Statistical analyses were performed using a one-way analysis of variance (ANOVA), and the significance of the mean difference was determined by Duncan’s multiple range test. Differences at p < 0.05 were considered statistically significant. The results are presented as mean values ± SD (standard deviations) of the three replicates. At the present study, a new rapid microcolumn RP-HPLC-UV method has been developed to simultaneously determine seven major phenolic compounds in the Potentilla anserina L. herb. The method showed a good linearity, precision, and accuracy, so it was suitable for quality control of the commercial samples of P. anserina L. herb. Ultrasound-assisted extraction was successfully employed to optimize the extraction, and several experimental parameters have been evaluated. The best combination of response functions was 60% acetone, a liquid-to-solid ratio of 40:1, and an extraction of 30 min at 40 °C under ultrasound irradiation of 100 W. In addition, 12 samples collected in different Siberian regions and two commercial herbs and preparations have been analyzed. The results warrant further discussion of the appropriate quality control of P. anserina pharmaceuticals. Phenolic Profile of Potentilla anserina L. (Rosaceae) Herb of Siberian Origin and Development of a Rapid Method for Simultaneous Determination of Major Phenolics in P. anserina Pharmaceutical Products by Microcolumn RP-HPLC-UV

Keep calm and try omega-3. The fatty acids, available as dietary supplements via fish oil capsules and thought to help with mental and physical well-being, could also cut down on aggression, according to a recent study. These findings haven't come out of nowhere: omega-3 has previously been linked to preventing schizophrenia, while aggression and antisocial behavior are thought in part to stem from a lack of nutrition. What we eat can influence our brain's chemistry. https://www.sciencealert.com/one-dietary-supplement-found-to-reduce-aggression-by-up-to-28

Food labels are widely used to convey the health benefits of conventional foods or a component of food (eg, nutrient) to the consumer. The increasing amount of health information available regarding the health benefits of foods has resulted in consumer interest in health issues and has become a leading factor in purchasing decisions. Therefore, labeling and advertising should not be misleading. The requirement to protect consumers and ensure their right to obtain accurate information on food functionality has led to the introduction of regulations about health claims worldwide. In the United States, health claims were first authorized by the US Food and Drug Administration (FDA) after enactment of the Nutrition Labeling and Education Act of 1990 (1). Health claims are made on the label or in the labeling of foods, including dietary supplements, that expressly or by implication (including “third party” references, written statements, symbols, or vignettes) characterize the relation between a substance and a disease or health-related condition (2). https://www.sciencedirect.com/science/article/pii/S0002916523239325

Digitalis heywoodii is a subspecies (ssp) of Digitalis purpurea L. that has not been thoroughly investigated. Differences and similarities exists between D. purpurea spp. heywoodii and D. pupurea from botanical (Silva and Silva, 1959; Werner, 1966; Valdes, 1987; Ayuso et al., 1991) and phytochemical (Lungeanu et al., 1963; Lungeanu, 1968) perspectives. This subspecies was discovered by Silva and Silva in 1959, however, no pharmacological study has been carried out on this taxon until now because of its small habitat. The presence of steroid glycosides in leaves of D. purpurea spp. heywoodii, was described by Langeanu et al., in 1963. Eight compounds have been isolated: lanatoside A, lanatoside B, purpurea glycoside A, purpurea glycoside B, glucoevatromonoside, glucolanatoside, digitalinum verum and strospeside. Although pharmacological effects of the plant extracts have been found previously (Ayuso et al., * Corresponding author. 1993; Navarro et al., 1994), it was decided to broaden the understanding about their cardiovascular activity. In 1930 Smith investigated an alternative plant source, the Digitalis lanata, and isolated from it the compound digoxin that is now commonly used when a cardiac glycoside is required. When in 1933 Stoll and Kreis crystallised digilanids, lanatosides A, B and C from D. lanata, the major components of both D. purpurea and D. lanata had been characterised (Stoll and Kreis, 1933). From a methanolic extract of leaves of D. purpurea spp. heywoodii we have identified four cardenolides: digitalinum verum, strospeside, purpureaglycoside A, and lanatoside A by its relative R as well as by direct comparison with authentic samples. On the other hand, a quantitative relationship does appear to exist between the cardiac action of extract and its emetic activity. The emetic potency of extract and digoxin was similar with doses 0.5 mg/kg and 40 mg/kg, respectively. In conclusion, early results of the pharmacological activity of methanolic extract of D. purpurea spp. heywoodii demonstrate that this plant has an interesting biological activity, due to the digitalis compounds present on it. There is a good methanolic extract: digoxin relationship with respect to the dose-response obtained with the different tests and the presence of gitoxin derivatives (digitalinum verum, strospeside). These compounds have been very rarely mentioned in the pharmacological literature (Abiko et al., 1965; Abiko and Ito, 1967; Abiko, 1967). Cardiovascular activity of a methanolic extract of Digitalis purpurea spp. heywoodii

Primula vulgaris belongs to the genus Primula, members of which are frequently used in folk medicine. Various studies have investigated the cytotoxic effect of different Primula species, but there have been limited studies on the cytotoxic effect of P. vulgaris. The aim of this study was to investigate the cytotoxic effects, and possible mechanisms involved, of P. vulgaris flower extract on human cervical cancer (HeLa) cells. The cytotoxic effect of the extract on HeLa cells was revealed using the MTT assay. Mechanisms involved in the extract's cytotoxic effect were then investigated in terms of apoptosis, mitochondrial membrane potential, and the cell cycle, using fluorometric methods. P. vulgaris flower extract exhibited selective cytotoxic effects against HeLa cells by arresting their cell cycle at the S phase, and inducing the number of apoptotic cells compared to normal fibroblast cells by reducing mitochondrial membrane potential in a concentration-dependent manner. This is the first study to reveal the antiproliferative effect of P. vulgaris flower extract. Further studies are now needed to identify the cytotoxic molecules in the extract and their mechanisms. Gentamicin and trypsin/EDTA solutions were obtained from Biological Industries (Kibbutz Beit Haemek, Israel), Eagle's minimum essential medium (EMEM) from Lonza (Verviers, Belgium), and fetal bovine serum (FBS) from Biochrom (Berlin, Germany). All flow cytometry kits were purchased from Becton Dickinson (San Diego, CA, USA). The other principal chemicals used were obtained from Sigma (St. Louis, MO, USA). This is the first study to examine the mechanisms involved in the in vitro cytotoxic effect of P. vulgaris flower extract on HeLa cells. Further studies are now needed for a more detailed understanding of the exact interaction of the signaling pathways involved. Primula vulgaris extract induces cell cycle arrest and apoptosis in human cervix cancer cells

A large number of chemotherapeutic and immunotherapeutic agents have been shown to be less effective when exposed to a hypoxic solid tumor. The tumor hypoxia microenvironment contributes to multidrug resistance and immunosuppression, and current delivery of oxygen or enzyme to alleviate hypoxic microenvironment is often limited by the oxygen supplying capacity of material-based carriers and short window of oxygen production. Herein, macrophage membrane coated chlorella (M-Chl) is constructed for targeted delivery to the solid tumor and sustainable oxygen production via photosynthesis, which provides a new general strategy to overcome tumor hypoxia and improve chemotherapy and immunotherapy. https://www.sciencedirect.com/science/article/abs/pii/S136970212200181X

In a study involving 11-year-olds, researchers have concluded that greater behavioral problems are linked to higher hair cortisol levels. The study also concluded that exposure to certain factors that can simultaneously cause chronic stress may determine the concentration of cortisol in the hair. https://www.sciencedaily.com/releases/2024/09/240903144923.htm

Given the right conditions, certain types of cells are able to self-assemble into new lifeforms after the organism they were once part of has died. Life and death are traditionally viewed as opposites. But the emergence of new multicellular life-forms from the cells of a dead organism introduces a "third state" that lies beyond the traditional boundaries of life and death .https://www.livescience.com/health/medicine-drugs/some-cells-can-enter-a-third-state-that-lies-beyond-the-traditional-boundaries-of-life-and-death-here-s-how

Fruits and vegetables or their natural constituents which increase detoxication enzymes and/or reduce activating enzymes are considered as good candidates to prevent chemically-induced carcinogenesis. In this study, rats were fed a diet supplemented with 20% onion powder for 9 days. Several cytochrome P450 (CYP)s enzymes (CYP 1A, 2B, 2E1, 3A), which are involved in carcinogen activation, were determined by measuring their enzyme activities using specific substrates. In addition, phase II enzymes activities such as UDP-glucuronosyltransferase (UGT) and glutathione S-transferase (GST), involved in detoxication of carcinogens, were measured. https://www.sciencedirect.com/science/article/abs/pii/S0278691501000564

Phytochemical and Pharmacological Properties of Capparis spinosa as a Medicinal Plant . C. spinosa is one of the most important economical species in the Capparidaceae family which has a wide range of diversity (i.e., about 40–50 genera and 700–900 species) . Capparidaceae has been known to be closely related to the family of the Brassicaceae (Cruciferae) that is rich in glucosinolates and flavonoids . C. spinosa is also known as Caper, wild watermelon (in China) . Cappero (in Italy), Alaf-e-Mar (in Persian) and Alcapparo (in Spain) . C. spinosa is a dicotyledonous perennial shrub which can grow up to 1 m high and has extensive root systems . It is native to the Mediterranean basin and widely distributed from Morroco to Crimea, Armernia, Iran . Several countries such as Greece, Italy, Spain and Turkey have widely produced C. spinosa. C. spinosa which is an aromatic plant is usually cultivated in tropical and subtropical regions . The most common propagation of C. spinosa is vegetative cuttings . It can flourish under dry hot conditions in either well-drained or poor soils. Although many studies using various parts of C. spinosa have reported diverse pharmacological activities including anti-diabetic and anti-hypertensive, there is still no conclusive information regarding the association between C. spinosa and its health benefits. This is because only a very few studies that involved human subjects examined the effect of C. spinosa consumption on human health. C. spinosa has the potential to be used for the treatment of hypertension. In a study of spontaneously hypertensive rats. A study by Gadgoli and Mishra evaluated the effects of C. spinosa on the antihepatotoxic on rats against paracetamol and carbontetrachloride induced toxicity in vivo. The underlying mechanism influencing human health by the consumption of C. spinosa still remains unclear. The effect of short- and long-term consumption of C. spinosa on human health therefore needs to be further evaluated. Furthermore, the role of the gut microbiota in the degradation of polyphenolic compounds present in the plant has not been considered. This aspect should be put forward in the perspectives .

https://www.midwesterndoctor.com/p/dmso-could-save-millions-from-brain DMSO (dimetil sulfoxid) este evidențiat în mai multe articole ca un potențial tratament revoluționar pentru leziunile cerebrale și ale măduvei spinării datorită capacității sale de a proteja celulele de stresul extrem, inclusiv ischemia (lipsa fluxului sanguin), îngheț și chiar șoc. Proprietățile sale unice îi permit să treacă prin membranele biologice fără a le deteriora, permițându-i să pătrundă în țesuturi, inclusiv în creier, în câteva minute de la administrare. Unul dintre principalele argumente în favoarea DMSO este potențialul său de a transforma tratamentul afecțiunilor neurologice traumatice, cum ar fi accidentele vasculare cerebrale, atacurile de cord și leziunile măduvei spinării. Prin stabilizarea proteinelor și reducerea deteriorării celulare, DMSO ar putea preveni leziunile permanente sau dizabilitatea. Compusul are, de asemenea, capacitatea de a îmbunătăți efectele altor medicamente, reducând în același timp toxicitatea acestora, ceea ce îl face un agent versatil pentru diverse aplicații medicale.

Researchers have shown that the balance of bacteria in the gut can influence symptoms of hypopituitarism in mice. They also showed that aspirin was able to improve hormone deficiency symptoms in mice with this condition.https://www.sciencedaily.com/releases/2024/09/240926144927.htm

Breast cancer is one of the major causes of mortality among women. Due to many side effects of the existing chemotherapeutic agents, the research of anti-cancer drugs, including natural products, is still a big challenge. Here, we investigated the effects of colchicine on apoptosis of two breast cancer cell lines ( human MCF-7 and mouse 4T1). n this experimental study, we evaluated the apoptotic effects of colchicine on (MCF-7) and (4T1), as well as a human cancer-associated fibroblast cell line as a control group. Extraction and chromatographic techniques were applied to isolate colchicine from Colchicum autumnale L. To compare the isolated colchicine with pure standard colchicine, we used the H-NMR technique. The methyl thiazolyl tetrazolium (MTT) assay, quantitative reverse transcriptase-polymerase chain reaction, Western blotting and annexin V/PI staining were used to evaluate the apoptotic effects of the isolated and standard colchicine. Results: Similar to standard colchicine, the isolated colchicine inhibited cell proliferation significantly in cancer cell lines. Colchine inhibited proliferation and induced apoptosis on a dose-dependent manner. The medicine modified the expression of genes-related to apoptosis by up-regulation of P53 ,BAX, CASPASE-3, -9 and down-regulation of BCL-2 gene, which led to an increase in the BAX/BCL-2 ratio. Conclusion: In this study, they showed that isolated colchicine from Colchicum autumnale and pure standard colchicines modulate the expression levels of several genes and therefore exerting their anticancer effects on both human (MCF-7) and mouse (4T1) breast cancer cells. Based on these results, we suggest that colchicine can be a potential candidate for prevention and treatment of breast cancer. Colchicine of Colchicum autumnale, A Traditional Anti-Inflammatory Medicine, Induces Apoptosis by Activation of Apoptotic Genes and Proteins Expression in Human Breast (MCF-7) and Mouse Breast (4T1) Cell Lines

This review reports on the effects of fermentation on the chemical constituents and antioxi- dant activity of plant-based food materials. Fermentation involves a series of reactions that modify the chemical components of the substrate. It could be considered a tool to increase the bioactive compounds and functional properties of food plant materials. Oxidative damage is key to the pro- gression of many human diseases, and the production of antioxidant compounds by fermentation will be helpful to reduce the risk of these diseases. Fermentation also can improve antioxidant activity given its association with increased phytochemicals, antioxidant polysaccharides, and antioxidant peptides produced by microbial hydrolysis or biotransformation. Additionally, fermentation can encourage the breakdown of plant cell walls, which helps to liberate or produce various antioxidant compounds. Overall, results indicated that fermentation in many cases contributed to enhancing antioxidants’ content and antioxidant capacity, supporting the fermentation use in the production of value-added functional food. This review provides an overview of the factors that impact the effects of fermentation on bioactive compound composition and antioxidant activity. The impacts of fermentation are summarized as a reference to its effects on food plant material. https://www.academia.edu/72525525/Fermentation_Affects_the_Antioxidant_Activity_of_Plant_Based_Food_Material_through_the_Release_and_Production_of_Bioactive_Components?email_work_card=view-paper

The aim was to formulate self-emulsifying drug delivery systems (SEDDS) to hasten dissolution and oral bioavailability of gliquidone (GLQ) as lipophilic oral hypoglycemic. In the developed formulations, cinnamon oil served as the oily phase, while Tween 20 and Transcutol® HP constituted the surfactant/cosurfactant system. A phase diagram was employed to select formulations showing transparent/translucent system after dispersion. These formulations were loaded with GLQ and subjected to in vitro dissolution studies relative to unprocessed GLQ. Optimum systems providing the fastest release were characterized for globule size and morphology. In addition, the in vivo hypoglycemic effect GLQ-loaded SEDDSs was assessed after oral administration to diabetic rats relative to GLQ aqueous dispersion (control). https://www.sciencedirect.com/science/article/abs/pii/S1773224724004908

The use of medicinal plants in treating illnesses has been reported since ancestral times. In the case of hepatic diseases, several species such as Silybum marianum, Phyllanthus niruri, and Panus giganteus (Berk.) have been shown to ameliorate hepatic lesions. Silymarin is a natural compound derived from the species Silybum marianum, which is commonly known as Milk thistle. This plant contains at least seven flavoligands and the flavonoid taxifolin. The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol, acetaminophen, and carbon tetrachloride. The liver is an important organ that has a key role in the maintenance of homeostasis. The liver is responsible for multiple metabolic functions and physiological processes such as bile production, energy generation, vitamin storage, and the metabolism of carbohydrates, proteins, and lipids. After intestinal absorption is complete the blood is rich in nutrients and xenobiotics. Silymarin is a natural compound that is present in species derived from Silybum marianum, which is commonly known as Milk thistle. The plant contains at least seven flavolignans and the flavonoid taxifolin. The most important flavolignans present include silybin, silydianin, and silychristine. In previous studies, the inherent hepatoprotective and antioxidant activity of silymarin was shown to be caused by its control of free radicals (FR), which are produced by the hepatic metabolism of toxic substances such as Et-OH, acetaminophen (Paracetamol), or carbon tetrachloride. There is substantial evidence suggesting that silymarin treatment improves hepatic diseases. However, some of the data are contradictory. Therefore, additional molecular studies investigating the mechanisms of action for these compounds are needed. It is known that silymarin does not possess adverse effects at high doses. Thus, it is a natural compound that is widely utilized in traditional medicine and has been investigated in formal scientific studies. Diverse hepatic damage models and ethanol injury have been utilized to study silymarin because ethanol is responsible for many cases of liver damage worldwide. The current data demonstrate that the use of silymarin treatment in alcoholic cirrhosis patients may attenuate the damage. However, silymarin treatment does not affect mortality. Hepatoprotective effect of silymarin

Researchers have uncovered the mechanisms that protect the genome from the metabolic toxin formaldehyde in AMeD, a rare congenital disorder of premature aging and myeloid leukemia development. The thttps://www.sciencedaily.com/releases/2024/09/240912135838.htmeam used human cells and a new animal model to recapitulate AMeD symptoms and their findings open the door to new therapeutic interventions.

Graviola, soursop, or guanabana (Annona muricata L.), is an ethnomedical fruit consumed to alleviate headache, diarrhea, diabetes, and cancer. Pericarp is the inedible part of graviola least studied in comparison to seeds and leaves, even thought, it contains the highest concentration of graviola total polyphenols. Anticancer effect of graviola pericarp has been demonstrated in crude extracts attributing the effect to acetogenins, however, crude extracts contain several active molecules. Thus, the present work aimed to fractionate and purify an ethanolic crude extract from graviola pericarp. Purified graviola pericarp fraction (PGPF) was evaluated on cancerous and non-cancerous cell lines, and then was identified by NMR, TOF-MS, and HPLC. Finally, an in silico analysis was performed to predict targets cancer-related of the molecule detected. https://www.sciencedirect.com/science/article/pii/S1878535222000363

https://www.mdpi.com/2311-5637/9/11/950 Studiul intitulat "Nattokinase: Insights into Biological Activity, Therapeutic Applications, and the Influence of Microbial Fermentation" explorează activitatea biologică și aplicațiile terapeutice ale nattokinazei, un enzimă fibrinolitică derivată din fermentarea boabelor de soia (natto). Nattokinaza a câștigat popularitate datorită capacității sale de a dizolva cheagurile de sânge și a fost asociată cu numeroase beneficii pentru sănătate, în special pentru sistemul cardiovascular. Principalele puncte discutate în studiu: Activitatea biologică: Nattokinaza posedă proprietăți fibrinolitice puternice, fiind capabilă să descompună fibrina, o proteină implicată în formarea cheagurilor de sânge. Acest lucru o face eficientă în prevenirea trombozelor și reducerea riscului de accidente vasculare cerebrale și infarcturi. Aplicații terapeutice: În afară de capacitatea sa de a preveni formarea cheagurilor, nattokinaza are și proprietăți antiinflamatorii și antioxidante, ceea ce sugerează potențiale beneficii în tratarea bolilor inflamatorii și a stresului oxidativ. Acest lucru o face relevantă în afecțiuni precum hipertensiunea, ateroscleroza și chiar în protecția organelor, cum ar fi ficatul. Influența fermentării microbiene: Procesul de fermentare cu Bacillus subtilis joacă un rol esențial în producerea nattokinazei, îmbunătățindu-i stabilitatea și biodisponibilitatea. Fermentarea nu doar că intensifică proprietățile enzimei, dar influențează și compoziția biochimică a produsului final, făcându-l mai eficient în aplicațiile clinice. Siguranță și eficacitate: Studiul subliniază că, deși nattokinaza a fost bine tolerată în studiile clinice, este necesară o cercetare suplimentară pentru a determina dozele optime și pentru a evalua efectele pe termen lung, mai ales în contextul administrării în paralel cu alte terapii anticoagulante.

Topical ozone therapy restores microbiome diversity in atopic dermatitis Ozonoterapia topică este foarte eficientă pentru tratarea dermatitei atopice. Poate modifica raportul proporțional dintre Staphylococcus și Acinetobacter, restabilind astfel diversitatea microbiologică în leziunile dermatitei atopice.

Ashwagandha and Rhodiola rosea are both popular adaptogenic herbs used in traditional medicine to help the body cope with stress and promote overall well-being. Both herbs may help with stress reduction, cortisol regulation, and mood improvement. While there is quite a bit of overlap between the herbs, they also have distinct characteristics and benefits. Rhodiola is known for its stimulating and energizing effects. It’s generally best taken earlier in the day, such as in the morning or before lunch, to avoid potential interference with sleep. Ashwagandha is traditionally associated with a calming and relaxing effect. Some people find it helpful to take ashwagandha in the evening, before bedtime, to promote relaxation and improve sleep quality. However, some individuals may also take it in the morning if they want to manage stress throughout the day. If you’re new to both herbs or uncertain about their effects on your body, you can start by taking them separately at different times of the day. This allows you to assess their individual effects and how they affect your energy levels and sleep. https://www.healthline.com/health/rhodiola-and-ashwagandha-together?utm_source=ReadNext#when-to-take-both

Chlorpropham is a selective and systemic herbicide extensively used to control sprouting, a major process affecting the quality of stored potatoes. Main concern about the usage of chlorpropham arises from the fact that chlorpropham degrades to toxic aniline-based metabolites during thermal processing of potatoes. The issue has led to chlorpropham withdrawal from the treatment practices, however, cross contamination from storage facilities requires ongoing monitoring of pesticide residues for a prolonged period. This study offers a fast and economic method suitable for chlorpropham screening in potatoes. The developed method targets the potato peel, simply prepared and analyzed by GC/MS. The method performance and cost-effectiveness were compared to that of the official method for chlorpropham analysis approved by the European Food Safety Authority. The method was used for the targeted analysis of potato samples from southeastern Serbia. https://www.sciencedirect.com/science/article/abs/pii/S0956713524004663

Passiflora edulis: An Insight Into Current Researches on Phytochemistry and Pharmacology Passiflora edulis, cunoscută și sub numele de fructul pasiunii, este distribuită pe scară largă în zonele tropicale și subtropicale ale lumii și devine populară datorită nutriției echilibrate și beneficiilor pentru sănătate. În prezent, au fost găsiți și identificați mai mult de 110 constituenți fitochimici din diferitele părți ale plantelor P. edulis, în care flavonoidele și triterpenoidele dețin cea mai mare pondere. Diverse extracte, sucuri de fructe și compuși izolați au prezentat o gamă largă de efecte asupra sănătății și activități biologice, cum ar fi activități antioxidante, antihipertensive, antitumorale, antidiabetice, hipolipidice și așa mai departe. Consumul zilnic de fructul pasiunii în doze comune este non-toxic și sigur. P. edulis are un mare potențial de dezvoltare și o vastă aplicație viitoare pentru această cultură importantă din punct de vedere economic la nivel mondial și este la mare căutare ca produs proaspăt sau formulă pentru alimente, produse de îngrijire a sănătății sau medicamente. Această mini-revizuire își propune să ofere informații reorganizate sistematic despre caracteristicile fizico-chimice, beneficiile nutriționale, activitățile biologice, toxicitatea și potențialele aplicații ale frunzelor, tulpinilor, fructelor și cojilor de P. edulis.

Interesant Andrei, insa cauta produsele celor de la SECOM. Fiecare membru cauta de la un anumit concurent.